Identification of hepadnavirus in the sera of cats

Identification of hepadnavirus in the sera of cats

Blog Article

Abstract Hepadnaviruses infect several animal species.The prototype species, human hepatitis B virus (HBV), increases the risk of liver diseases and may cause cirrhosis and hepatocellular carcinoma.Recently a novel hepadnavirus, similar to HBV, has been identified through transcriptomics studies in a domestic cat with large cell lymphoma in Australia.Herewith, a collection of 390 feline serum samples was icon track bar f250 screened for hepadnavirus.

Overall, the virus was identified in 10.8% of the sera with a significantly higher prevalence (17.8%) in the sera of animals with a clinical suspect of infectious disease.Upon genome sequencing, the virus was closely related (97.

0% nt identity) to the prototype Australian feline virus Sydney 2016.The mean and median values of hepadnavirus in the feline sera were 1.3 × 106 and 2.1 × 104 genome copies per mL (range 3.

3 × 100–2.5 × 107 genome copies per mL).For a subset of hepadnavirus-positive samples, information on the hemato-chemical parameters was available and in 10/20 animals a profile suggestive of liver damage was present.Also, in 7/10 animals with suspected hepatic disease, virus load was >104 genome copies per arcade smokey the bear belt mL, i.

e.above the threshold considered at risk of active hepatitis and liver damage for HBV.